19 KiB
19 KiB
| 1 | Unnamed:0 | sentence | ent_nut | ent_pos | ent_neg | sta_nut | sta_sup | sta_opp | senti | med_aff | med_treat | label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | 0 | there are also any therapies , such as progestogens and testosterone | -0.30793682 | -0.093838915 | -0.30793682 | 2.547167699 | 2.96220066 | 2.045056567 | Negative | 0 | 0 | neutral |
| 3 | 1 | the study , published in the april for , 2007 , issue of jama , also discovered that increased risk of heart disease in older women occurs primarily in those who have hot flashes and night sweats , though it remains unclear whether this explained their higher risk on hormone therapy | -0.30707675 | -0.08727121 | -0.30707675 | 2.834073555 | 3.044572391 | 2.179508396 | Negative | 0 | 0 | oppose |
| 4 | 2 | benefits and risks of identical hormones are the same as for other hormone products , according to the you is food and drug administration | -0.30872616 | -0.096462406 | -0.30872616 | 3.430434401 | 3.639866758 | 2.846244414 | Negative | 0 | 0 | neutral |
| 5 | 3 | researchers warned that even taking the treatment for less than five years , as is common medical practice , increased the risk of succumbing to ovarian cancer | -0.3079363 | -0.08664638 | -0.3079363 | 3.657244569 | 3.825910638 | 3.132719765 | Negative | 0 | 0 | oppose |
| 6 | 4 | ovarian cancer is a rare condition but all the risks and benefits of hormone therapy need to be carefully considered when treating women at menopause | -0.30827823 | -0.09138498 | -0.30827823 | 2.373167746 | 2.539500035 | 1.800853847 | Positive | 0 | 0 | neutral |
| 7 | 5 | progestin is a synthetic version of progesterone , a hormone that helps protect the uterus | -0.30875805 | -0.09864901 | -0.30875805 | 3.414447068 | 3.393808375 | 2.467214805 | Positive | 0 | 0 | neutral |
| 8 | 6 | in the decade since , combined hrt use has declined , as have rates of estrogen receptor positive breast cancer in post menopausal women | -0.30815196 | -0.08973856 | -0.30815196 | 2.336270554 | 2.380297834 | 1.786690794 | Negative | 0 | 0 | oppose |
| 9 | 7 | this is thought to be linked to the amount of estrogen in your body , because being overweight or obese after the menopause causes more estrogen to be produced | -0.3088132 | -0.09773825 | -0.3088132 | 3.338902196 | 3.435928287 | 2.071471014 | Negative | 0 | 0 | neutral |
| 10 | 8 | and in 2010 , the news about combined hrt contributing to more deadly forms of breast cancer and mortality led more practitioners to reconsider the way they counseled women about hormone therapy , according to some reports | -0.30754536 | -0.08083202 | -0.30754536 | 2.1323124 | 2.402513485 | 1.846943373 | Negative | 0 | 0 | oppose |
| 11 | 9 | therefore , for some years doctors have recommended that the only women who should take estrogen without progestin on a continuous basis are women who have had a hysterectomy | -0.3085171 | -0.094150886 | -0.3085171 | 2.425105409 | 2.693570413 | 2.044716636 | Negative | 0 | 0 | neutral |
| 12 | 10 | after five years of taking a combination of estrogen and synthetic progesterone , women in the national whi clinical were found to be at such high risk for life threatening diseases such as cancer , that their portion of the trial was halted three years early in 2002 | -0.3069025 | -0.0817275 | -0.3069025 | 2.849977652 | 2.912503627 | 2.317272639 | Negative | 0 | 1 | oppose |
| 13 | 11 | these data suggest that the increased risk for breast cancer that accompanies use of hrt is reversible within a fairly short period following discontinuation of the treatment | -0.3080357 | -0.08815504 | -0.3080357 | 2.352492447 | 2.729722756 | 2.136390771 | Negative | 0 | 0 | oppose |
| 14 | 12 | researchers studied medical records dating as far back as 1973 of 44 , 421 women on ert and found they had at least a 60 percent higher risk of ovarian cancer than women who had never used hormone replacement therapy | -0.3069059 | -0.08183149 | -0.3069059 | 3.134267617 | 3.369874395 | 2.694870006 | Negative | 0 | 0 | oppose |
| 15 | 13 | during menopause , a woman is body begins to produce less estrogen and progesterone | -0.30881995 | -0.09878824 | -0.30881995 | 3.845651997 | 4.132146009 | 2.771892692 | Negative | 0 | 0 | neutral |
| 16 | 14 | the risks of hormone therapy may vary depending on whether estrogen is given alone or with a progestin , and depending on your current age and age at menopause , the dose and type of estrogen , and other health risks such as your risks of heart and blood vessel ( cardiovascular ) disease , cancer risks and family medical history | -0.30817118 | -0.09645873 | -0.30817118 | 3.470186311 | 3.640833808 | 2.852981702 | Negative | 0 | 0 | neutral |
| 17 | 15 | and in 2010 , new research found that combined estrogen progestin hrt increased the risk for more severe forms of breast cancer and increased a woman 's chances of dying from the disease or other causes | -0.3076002 | -0.08152002 | -0.3076002 | 2.716766431 | 2.76952089 | 2.150593851 | Negative | 0 | 0 | oppose |
| 18 | 16 | not only were women more likely to develop breast cancer if they took the hormones , researchers wrote , but their tumors tended to be larger and more advanced than breast cancers that developed in women who took a placebo | -0.30769223 | -0.08262344 | -0.30769223 | 3.210784267 | 3.383193594 | 2.910005783 | Negative | 0 | 0 | oppose |
| 19 | 17 | still , even in these cases , women should be on the minimum dose to relieve their symptoms and consider tapering off of their medications over time | -0.3086599 | -0.09579289 | -0.3086599 | 3.877901335 | 3.973362226 | 3.051769469 | Negative | 0 | 0 | neutral |
| 20 | 18 | hrt may help alleviate some symptoms | -0.30859855 | -0.09790066 | -0.30859855 | 2.095524598 | 2.31174914 | 1.117700771 | Neutral | 0 | 1 | support |
| 21 | 19 | good diet will help lower your risk of bone loss , which increases as you age | -0.30882347 | -0.09769264 | -0.30882347 | 3.767434473 | 3.773437241 | 2.611115271 | Negative | 0 | 0 | neutral |
| 22 | 20 | estrogen only hrt can only be given to women who have had a hysterectomy ( they have no uterus ) | -0.30845863 | -0.09722622 | -0.30845863 | 3.509999536 | 3.678716695 | 2.993614979 | Negative | 0 | 0 | neutral |
| 23 | 21 | you may notice breast tenderness , headaches , bloating , and mood changes while you 're on hormone replacement therapy , especially if you 're taking progestin | -0.3084086 | -0.092950344 | -0.3084086 | 2.714165671 | 2.866918964 | 2.225723825 | Negative | 0 | 0 | oppose |
| 24 | 22 | the daily telegraph and other newspapers reported that these 2002 findings triggered a collapse in confidence in hormone replacement therapy and the number of women taking it halved | -0.30809474 | -0.08888988 | -0.30809474 | 2.194483715 | 2.559606195 | 1.755252108 | Negative | 0 | 0 | oppose |
| 25 | 23 | all of these risks should be considered in deciding whether hormone therapy might be an option for you | -0.3088696 | -0.0986024 | -0.3088696 | 2.412536685 | 2.412531972 | 1.859117721 | Negative | 0 | 0 | neutral |
| 26 | 24 | other studies soon found hrt also increased the risk of alzheimer 's , dementia , and asthma | -0.30881423 | -0.097706586 | -0.30881423 | 2.353111706 | 2.43413074 | 1.964736599 | Negative | 0 | 0 | oppose |
| 27 | 25 | women should not stop hormone therapy based on this study but if they are concerned they should discuss the findings with their doctor | -0.30869198 | -0.096094966 | -0.30869198 | 3.32250668 | 3.530528905 | 2.596425359 | Neutral | 0 | 0 | neutral |
| 28 | 26 | originally planned as a five year study , the swedish trial was stopped earlier due to its adverse outcomes in women taking hrt | -0.30819488 | -0.09023826 | -0.30819488 | 2.708376597 | 2.781670033 | 2.201885748 | Negative | 0 | 0 | oppose |
| 29 | 27 | the good news is that after women stop taking combination hormone therapy , their risk of heart disease appears to decrease , said elizabeth g nabel , md , nhlbi director | -0.3078584 | -0.08549101 | -0.3078584 | 2.536012623 | 2.87582555 | 2.199505213 | Negative | 0 | 0 | oppose |
| 30 | 28 | hrt can also help to lower the risk of osteoporosis and prevent some of the long term health problems associated with early menopause | -0.3081553 | -0.08975121 | -0.3081553 | 2.720829521 | 2.853129972 | 1.928561432 | Negative | 0 | 0 | support |
| 31 | 29 | ovarian cancer is the fifth most common cause of cancer death among women in the uk , accounting for six per cent of all female deaths from cancer | -0.307868 | -0.0854373 | -0.307868 | 3.091152425 | 3.270706424 | 2.505033435 | Negative | 0 | 0 | neutral |
| 32 | 30 | this finding is consistent with the rapid drop in post menopausal breast cancer incidence rates since 2002 , a decrease that has been attributed to the precipitous drop in hrt prescriptions in white , middle upper class post menopausal women following the release of the data from these large studies | -0.30746105 | -0.09130402 | -0.30746105 | 2.741885567 | 3.064734385 | 2.289333268 | Neutral | 0 | 0 | oppose |
| 33 | 31 | this part of the study , reported in jama , also found that the estrogen progestin therapy was ineffective in preventing mild cognitive impairment , a dimming of cognitive function that is less severe than dementia and which sometimes occurs as we age | -0.30732015 | -0.0799837 | -0.30732015 | 2.742238786 | 3.057965172 | 2.276142988 | Negative | 0 | 0 | oppose |
| 34 | 32 | this new analysis did not suggest that the original studies were poorly performed but it did highlight limitations to what the studies can tell us | -0.30846593 | -0.09351822 | -0.30846593 | 2.461886362 | 2.847428277 | 1.882034779 | Negative | 0 | 0 | neutral |
| 35 | 33 | if you are at risk of heart disease or osteoporosis , and lifestyle changes do n't seem to be working , there are many prescription drugs available to help ward off those conditions | -0.30795097 | -0.08678055 | -0.30795097 | 3.49121679 | 3.474477276 | 2.558986315 | Negative | 0 | 0 | neutral |
| 36 | 34 | an analysis by whi investigators found that hrt caused or worsened urinary incontinence in participants in the trial | -0.3087759 | -0.09717251 | -0.3087759 | 3.246189878 | 3.49120175 | 2.455190472 | Negative | 0 | 0 | oppose |
| 37 | 35 | if you do use hrt , you 'll need to have an annual checkup , including a blood pressure check , breast and pelvic exams , and a pap test | -0.30842435 | -0.09309043 | -0.30842435 | 2.957847384 | 2.674857512 | 1.904815917 | Negative | 0 | 0 | neutral |
| 38 | 36 | a study of one million women , run by cancer research uk scientists , has shown that different types of hrt can increase the risk of different cancers | -0.30785528 | -0.085293464 | -0.30785528 | 2.509126786 | 2.718816695 | 2.055899761 | Negative | 0 | 0 | oppose |
| 39 | 37 | in 2003 , swedish researchers halted a study of hrt in women , because women taking hrt had three times the rate of recurrence or of new tumors compared to women who received other treatments for menopausal symptoms | -0.30746078 | -0.08055104 | -0.30746078 | 2.379038079 | 2.579869263 | 2.103801697 | Negative | 0 | 0 | oppose |
| 40 | 38 | long term systemic hormone therapy for the prevention of postmenopausal conditions is no longer routinely recommended | -0.3087033 | -0.09622737 | -0.3087033 | 3.129010057 | 3.364180387 | 2.43654229 | Negative | 0 | 0 | oppose |
| 41 | 39 | hormone therapy ( as it 's now called ) was also thought to have the long term benefits of preventing heart disease and possibly dementia | -0.3083598 | -0.09232032 | -0.3083598 | 2.811513571 | 3.00582123 | 2.18292013 | Negative | 0 | 0 | support |
| 42 | 40 | the cardiovascular and cancer risks of estrogen plus progestin outweigh any benefits and a 26 percent increase in breast cancer risk is too high a price to pay , even if there were a heart benefit , said claude lenfant , md , director of the national heart , lung , and blood institute , the agency that halted the study | -0.30832523 | -0.0974669 | -0.30832523 | 2.677202793 | 2.748173154 | 2.163704957 | Negative | 0 | 0 | oppose |
| 43 | 41 | several newspapers have today reported that hormone replacement therapy ( hrt ) does not increase the risk of breast cancer | -0.30865663 | -0.09572742 | -0.30865663 | 2.148900656 | 2.417965737 | 2.029731487 | Negative | 0 | 0 | support |
| 44 | 42 | this is because estrogen alone , when not balanced by progesterone , can stimulate growth of the lining of the uterus , increasing the risk of uterine cancer | -0.30869645 | -0.09629091 | -0.30869645 | 3.722951817 | 3.827153839 | 3.055341446 | Negative | 0 | 0 | support |
| 45 | 43 | for patients who are at higher risk of breast cancer , bitner explores alternative therapies for menopausal symptoms that will reduce exposure to progesterone | -0.30848405 | -0.09390345 | -0.30848405 | 2.869151337 | 3.023534938 | 1.841367537 | Negative | 0 | 1 | oppose |
| 46 | 44 | as mentioned , doctors choose to prescribe progestin along with estrogen because estrogen taken alone can increase the risk of uterine cancer , unless you 've had a hysterectomy | -0.3081885 | -0.09033902 | -0.3081885 | 3.240761876 | 3.260867933 | 2.503720441 | Negative | 0 | 0 | oppose |
| 47 | 45 | this was a reanalysis of three studies suggesting that hrt caused an increased risk of breast cancer , to see whether the association was actually causal | -0.3081378 | -0.08949575 | -0.3081378 | 2.520937941 | 2.76604425 | 2.193200365 | Negative | 0 | 0 | neutral |
| 48 | 46 | despite the health risks , systemic estrogen is still the most effective treatment for menopausal symptoms | -0.30876863 | -0.09709254 | -0.30876863 | 2.617981063 | 2.84178476 | 1.829604119 | Negative | 0 | 1 | support |
| 49 | 47 | results showed that women were at increased risk of breast cancer while taking combination hrt | -0.3088155 | -0.09753017 | -0.3088155 | 1.8582676 | 1.909077563 | 1.754237851 | Neutral | 0 | 0 | oppose |
| 50 | 48 | there is no evidence that hrt or vaginal estrogen after treatment for cervical cancer stimulates your cervical cancer to grow again | -0.30879354 | -0.09749718 | -0.30879354 | 2.606058341 | 2.732613598 | 2.216985096 | Negative | 0 | 1 | support |
| 51 | 49 | researchers found that women taking estrogen combined with progesterone had a 39 percent greater risk of urinary incontinence than participants taking a placebo | -0.30808687 | -0.08890947 | -0.30808687 | 3.209855411 | 3.383556061 | 2.735642798 | Negative | 0 | 0 | oppose |
| 52 | 50 | the revised absolute risk increase appears to now sit at just under 1 extra case per 10 , 000 women per year somewhat less than the study initially suggested | -0.30760264 | -0.081312954 | -0.30760264 | 3.193392492 | 3.488644401 | 2.855894919 | Negative | 0 | 0 | neutral |
| 53 | 51 | but a study reported in the journal of the american medical association links the use of estrogen alone as a hormone replacement therapy to a possible increase in the risk of ovarian cancer | -0.30780262 | -0.08448333 | -0.30780262 | 2.815100684 | 3.049462138 | 2.405854236 | Negative | 0 | 0 | oppose |
| 54 | 52 | the analysis found that all three studies failed to meet the majority of the criteria and therefore none of the studies was able to establish whether hrt increases the risk of breast cancer | -0.30769974 | -0.082803644 | -0.30769974 | 2.787318489 | 2.83122364 | 2.183630672 | Negative | 0 | 0 | support |
| 55 | 53 | a 2002 study called the women 's health initiative ( whi ) , designed to explore the benefits and risks of combined estrogen progestin hrt was halted three and a half years before the intended end of the study period , because researchers observed a 26 percent increase in the relative risk of breast cancer | -0.30830973 | -0.097342074 | -0.30830973 | 2.756191461 | 2.775659549 | 2.262245104 | Negative | 0 | 0 | oppose |
| 56 | 54 | the women on combined hrt had a 41 percent increase in the rate of strokes , twice the number of blood clots , and a 26 percent increase in invasive breast cancer rates | -0.3077081 | -0.08297766 | -0.3077081 | 2.583531161 | 2.891198157 | 2.379310104 | Negative | 0 | 1 | oppose |
| 57 | 55 | there is an increased risk of breast cancer with hrt , which has been well documented | -0.30879873 | -0.09879543 | -0.30879873 | 2.015173367 | 2.061947692 | 2.026816363 | Negative | 0 | 0 | oppose |
| 58 | 56 | in the uk , for every 1000 women using any type of hrt for 5 years from age 50 there is thought to be 1 extra case of ovarian cancer | -0.3079883 | -0.08739048 | -0.3079883 | 3.145508991 | 3.433063284 | 2.587915004 | Negative | 0 | 0 | oppose |
| 59 | 57 | study suggests progestin , not estrogen , is the real cancer culprit in hormone replacement therapy | -0.30882147 | -0.097747646 | -0.30882147 | 2.126203516 | 2.548807318 | 1.834764235 | Negative | 0 | 0 | neutral |
| 60 | 58 | in 2007 , a similar oxford university study concluded that 1 , 000 british women may have died from ovarian cancer since 1991 because they have taken hrt | -0.30785704 | -0.0852113 | -0.30785704 | 2.07426957 | 1.979290655 | 1.598604251 | Negative | 0 | 0 | oppose |
| 61 | 59 | in the days since the study was released examination of the relative and absolute risk calculations have shown them to be incorrect | -0.3087587 | -0.096877135 | -0.3087587 | 2.280893756 | 2.724576967 | 1.830807574 | Negative | 0 | 0 | oppose |
| 62 | 60 | a leading cancer charity said this was a modest increase on a relatively uncommon cancer | -0.30885404 | -0.09816538 | -0.30885404 | 1.269149216 | 1.643768647 | 1.473616675 | Neutral | 0 | 0 | oppose |
| 63 | 61 | scientists behind the latest study , which looked at data from 52 separate studies including 21 , 500 women with ovarian cancer , say it proves there is a link between hrt and ovarian cancer | -0.3076241 | -0.08175199 | -0.3076241 | 2.166146556 | 2.173568536 | 1.65943666 | Negative | 0 | 0 | oppose |
| 64 | 62 | for example , if you started your periods at a young age and experienced the menopause at a late age , you 'll have been exposed to estrogen over a longer period of time | -0.3081779 | -0.090026505 | -0.3081779 | 4.356595397 | 4.376262813 | 3.157884585 | Negative | 0 | 0 | neutral |
| 65 | 63 | since the results of the whi were initially published , other large studies have supported its major conclusions of hrt causing breast cancer | -0.30839032 | -0.09267678 | -0.30839032 | 2.828576937 | 2.869906254 | 2.333782821 | Negative | 0 | 0 | oppose |
| 66 | 64 | further , carefully designed studies are needed to determine whether hrt does indeed cause an increased risk of breast cancer | -0.308426 | -0.09311984 | -0.308426 | 2.368978117 | 2.183204882 | 1.784261919 | Negative | 0 | 0 | neutral |
| 67 | 65 | the benefits of hormone therapy may outweigh the risks if you 're healthy and experience moderate to severe hot flashes or other menopausal symptoms , have lost bone mass and either ca n't tolerate or are n't benefitting from other treatments , stopped having periods before age 40 ( premature menopause ) or lost normal function of your ovaries before age 40 ( premature ovarian insufficiency ) | -0.30909488 | -0.10132985 | -0.30909488 | 3.471716379 | 3.838192538 | 2.412545802 | Negative | 0 | 0 | support |
| 68 | 66 | also in 2003 , researchers in the million women study in the united kingdom reported that the use of all types of post menopausal hrt resulted in a statistically significant increase in the risk of breast cancer | -0.3075403 | -0.08100999 | -0.3075403 | 2.18133633 | 2.422945328 | 1.942395179 | Negative | 0 | 0 | oppose |
| 69 | 67 | women who are taking hrt for menopausal symptoms or who used to take hrt should note the advice from cancer help uk , which states that any cancer risk associated with hrt reduces to a normal level five years after you stop taking hrt | -0.30694425 | -0.08107502 | -0.30694425 | 2.507583382 | 2.577409466 | 1.909358843 | Negative | 0 | 1 | oppose |
| 70 | 68 | the researchers wanted to determine whether the association between hrt and breast cancer actually showed that hrt caused an increased risk in breast cancer | -0.3080565 | -0.08845728 | -0.3080565 | 2.247817132 | 2.281942912 | 1.93500042 | Neutral | 0 | 0 | neutral |
| 71 | 69 | between 1995 and 2000 , several epidemiological studies indicated that use of combined estrogen progestin hormone replacement therapy ( hrt ) treatments led to an increase in invasive breast cancer | -0.30767825 | -0.08266117 | -0.30767825 | 2.706323583 | 2.901532449 | 2.35708758 | Negative | 0 | 1 | oppose |
| 72 | 70 | the risk continues to increase slightly the longer you take hrt , but returns to normal once you stop taking it | -0.30872878 | -0.09648016 | -0.30872878 | 2.83325092 | 2.867143052 | 2.42323505 | Positive | 0 | 0 | oppose |
| 73 | 71 | today is news reports are based on a new analysis of the data from the million women study and two other studies | -0.30828375 | -0.09134959 | -0.30828375 | 1.379827443 | 1.973155554 | 1.285420511 | Neutral | 0 | 0 | neutral |
| 74 | 72 | the university of oxford research , in the lancet , found an extra case for every 1 , 000 women taking the drugs for five years from the age of 50 | -0.3078089 | -0.08437845 | -0.3078089 | 3.452466684 | 3.649308362 | 2.96417741 | Negative | 0 | 0 | oppose |
| 75 | 73 | hrt which uses estrogen only increases the risk of womb cancer | -0.30875129 | -0.09855753 | -0.30875129 | 2.54994758 | 2.62290526 | 2.270309757 | Neutral | 0 | 0 | oppose |